Indium, cake

Water solubility

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Principles of method if other than guideline:

The substance is dissolved in water at a temperature somewhat above the test temperature, such that a portion of the substance remains
undissolved. When saturation is achieved, the mixture is cooled and kept at the test temperature until equilibrium is reached. Subsequently, the mass concentration of indium in the aqueous solution, which must not contain any undissolved particles, is determined by ICP.

GLP compliance:

not specified

Type of method:

flask method

Key result

Water solubility:

< 1 mg/L

Conc. based on:

element (dissolved fraction)

Loading of aqueous phase:

100 g/L

Incubation duration:

>= 72 - <= 120 h

Temp.:

20 °C

pH:

5.5

Conclusions:

Interpretation of results: slightly soluble (0.1-100 mg/L)
Test carried out according to standard protocol, test results consistent, thus reliable for concluding on endpoint.

Executive summary:

The water solubility of Indium cake was determined according to OECD guideline no. 105 [adopted on 27 July 1995] and EU test method A.6 [Council Regulation (EC) No 440/2008] with the flask method.

Water solubility (at 20 °C ± 0.5 °C) of Indium cake: <1 mg/l

Reference 2

Endpoint:

transformation / dissolution of metals and inorganic metal compounds

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Series on Testing and Assessment No. 29 (23-Jul-2001): Guidance document on transformation/dissolution of metals and metal compounds in aqueous media

GLP compliance:

yes

Type of method:

other: transformation dissolution protocol

Type of test:

full transformation/dissolution test - metals and sparingly soluble metal compounds

Mean dissolved conc.:

0.42 µg/L

Element analysed:

Pb

Loading of aqueous phase:

1 mg/L

Incubation duration:

7 d

Test conditions:

pH=6

Key result

Type of test:

full transformation/dissolution test - metals and sparingly soluble metal compounds

Mean dissolved conc.:

10 µg/L

Element analysed:

Pb

Loading of aqueous phase:

1 mg/L

Incubation duration:

28 d

Test conditions:

pH=6

Type of test:

full transformation/dissolution test - metals and sparingly soluble metal compounds

Mean dissolved conc.:

66.7 µg/L

Element analysed:

Cd

Loading of aqueous phase:

1 mg/L

Incubation duration:

7 d

Test conditions:

pH=6

Key result

Type of test:

full transformation/dissolution test - metals and sparingly soluble metal compounds

Mean dissolved conc.:

74.2 µg/L

Element analysed:

Cd

Loading of aqueous phase:

1 mg/L

Incubation duration:

28 d

Test conditions:

pH=6

Details on results:

The temperature of the test solutions fluctuated between 21.2 and 22.7°C during the tests, the pH remained constant at ± 0.2 units, and the dissolved oxygen concentration was always maintained above 70% (± 5.95 mg/L) of its saturation in air (± 8.50 mg/L). The non-purgeable dissolved organic carbon content (NPDOC) of the (modified) ISO 6341 aqueous media was below the reporting limit (<0.5 mg/L).
The acute (7d) Transformation/Dissolution Test on In cake in a standard aqueous medium at pH 6 and with a 1 mg/L loading showed an average dissolved cadmium concentration of 66.7 μg/L Cd, 0.42µg/l Pb. In cake contains 7.67% (w/w) cadmium and 1% Pb. This means that 87% of the total introduced cadmium and 4.2% of the Pb went into the test system as dissolved cadmium/Pb after 7 days.
The Chronic (28d) Transformation/Dissolution Test on In cake in a standard aqueous medium at pH 6 and with a 1 mg/L loading showed an average dissolved cadmium concentration of 74.2μg/L Cd and lead concentration of 1µg/l Pb. This means that about 97% of the total introduced cadmium went into the test system as dissolved cadmium after 28 days and 10% Pb.

Conclusions:

Interpretation of results: slightly soluble (0.1-100 mg/L)
Tests were done according to standard OECD protocol and considered of good quality.

Executive summary:

In this study, a loading of 1 mg/L of In cake was agitated at 100 rpm in a pH buffered aqueous medium at pH 6 for 28 days. The solutions were sampled at specific time intervals and the concentrations of dissolved Cd/Pb/In in water were determined.

The acute (7d) Transformation/Dissolution Test on In cake in a standard aqueous medium at pH 6 and with a 1 mg/L loading showed an average dissolved cadmium concentration of 66.7 μg/L Cd and 0.42µg/L Pb.

The Chronic (28d) Transformation/Dissolution Test on In cake in a standard aqueous medium at pH 6 and with a 1 mg/L loading showed an average dissolved cadmium concentration of 74.2 μg/L Cd and 1µg/L Pb.

Description of key information

Water solubility for indium (at 20 °C ± 0.5 °C) of Indium cake: <1 mg/l

Key value for chemical safety assessment

Water solubility:

0.5 mg/L

at the temperature of:

20 °C

Additional information

In the Transformation-dissolution study, a loading of 1 mg/L of In cake was agitated at 100 rpm in a pH buffered aqueous medium at pH 6 for 28 days. The solutions were sampled at specific time intervals and the concentrations of dissolved Cd/Pb/In in water were determined.

The acute (7d) Transformation/Dissolution Test on In cake in a standard aqueous medium at pH 6 and with a 1 mg/L loading showed an average dissolved cadmium concentration of 66.7 μg/L Cd and 0.42µg/L Pb.

The Chronic (28d) Transformation/Dissolution Test on In cake in a standard aqueous medium at pH 6 and with a 1 mg/L loading showed an average dissolved cadmium concentration of 74.2 μg/L Cd and 1µg/L Pb.

The substance is therefore considered slightly soluble