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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Effects on developmental toxicity

Description of key information
The pre-natal developmental toxicity of 1 -H-Tetrazol-5-amine-,N-1 H-tetrazol-5- yl-,monoammonium salt was investigated according to US-EPA Guideline OPPTS 870.3700.
The maternal No-Observable-Adverse-Effect Level (NOAEL) and the No-Observable-Effect Level (NOEL) for developmental toxicity in this developmental toxicity study in rats with 1 -H-Tetrazol-5amine-,N-1 H-tetrazol-5- yl-,monoammonium salt was 200 mg/kg/day.
Effect on developmental toxicity: via oral route
Endpoint conclusion:
adverse effect observed
Dose descriptor:
200 mg/kg bw/day
Study duration:
Quality of whole database:
One reliable GLP-study is available.
Additional information
Justification for selection of Effect on developmental toxicity: via oral route:
Reliable without restrictions

Justification for classification or non-classification

Developmental toxicity was manifested when given at a dosage which indicate clearly recognizable general maternal toxicity.Therefore, classification of 1 -H-Tetrazol-5amine-,N-1 H-tetrazol-5-yl-,monoammoniumsalt for developmental toxicity based on non-maternal mediated pup toxicity is not justified.

Additional information