Registration Dossier
Registration Dossier
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EC number: 485-280-6 | CAS number: 303749-96-4
Endpoint summary
Administrative data
Description of key information
The test item 1H-TETRAZOL-5-AMINE-,N-1H-TETRAZOL-5-YL-, MONOAMMONIUMSALT was administered by oral route to a group of 6 female Sprague Dawley rats at the single dose of 2000 mg/kg body weight according to OECD Guideline 423.The results obtained, under these experimental conditions, enable to conclude that the LD50of the test item 1H-TETRAZOL-5AMINE-,N-1H-TETRAZOL-5-YL-, MONOAMMONIUM SALT is higher than 2000 mg/kg body weight by oral route in the rat.
The test item 1H-TETRAZOL-5-AMINE-,N-1H-TETRAZOL-5-YL-, MONOAMMONIUM SALT was applied onto the intact skin of 10 Sprague Dawley rats (5 males and 5 females) at the single dose of 2000 mg/kg body weight according to OECD Guideline 402.
The LD50 of the test item 1H-TETRAZOL-5-AMINE-,N-1H-TETRAZOL-5-YL-, MONOAMMONIUM SALT is higher than 2000 mg/kg body weight by dermal route in the rat.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- Reliable without restrictions
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- Reliable without restrictions
Additional information
One reliable GLP-study is available.
Justification for selection of acute toxicity – dermal endpoint
One reliable GLP-study is available.
Justification for classification or non-classification
According to the criteria for classification, packaging and labelling of dangerous substances and preparations in accordance with the E.E.C. Directives 67/548, 2001/59 and 99/45, the test item 1H- TETRAZOL-5AMINE-,N-1H-TETRAZOL-5-YL-, MONOAMMONIUM SALT needs not to be classified. No symbol and risk phrase are required.
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