Registration Dossier
Registration Dossier
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EC number: 244-169-0 | CAS number: 21049-70-7
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
The test substance is soluble in water and dissociates.
Since no studies on the aquatic toxicity of 2-(methylamino)ethanol, compound with sulphur dioxide are available, study reports about the toxic effects of 2-(methylamino)ethanol and substances of the sulphite category have been consulted alternatively.
The acute toxicity of 2-(methylamino)ethanol (CAS 109-83-1) to microorganisms was examined in a guideline study according to OECD 209 [BASF AG, 1993] using domestic activated sludge as inoculum. At test termination after 30 minutes, an EC20 > 1000 mg/L was determined.
A respiration inhibition test was conducted with the read-across substance sodium sulfite Na2SO3(CAS 7757-83-7) according to OECD guideline 209 [ECT 2010]. No respiratory effects were noticed at 1000 mg Na2SO3/L. Thus, the NOEC expressed as SO32-was equal to (or higher than) 634.4 mg/L.
Supporting growth inhibition tests with the bacteria Pseudomonas putida were conducted with three different sulphite compounds: potassium sulphite K2SO3(CAS 10117-38-1), disodium disulphite Na2S2O5(CAS 7681-57-4) and dipotassium disulphite K2S2O5(CAS 16731-55-8) [BASF AG, 1988].At test termination after 17 hours, results show EC10 values ranging from 23.1 - 77.4 mg SO32-/L. As the respiration inhibition test with activated sludge is a more relevant test design for evaluating effects of a substance on microorganisms, and taking into account that the ECT-study was conducted as GLP-compliant OECD guideline study, these data (i.e. NOEC >= 634.4 mg/L) are put forward for the effects assessment of sulphite/disulphite compounds towards microorganisms.
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