Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 909-122-7 | CAS number: -
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable study report which meets basic scientific principles
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
- Reference Type:
- secondary source
- Title:
- Fragrance raw materials monographs
- Author:
- Ford RA
- Year:
- 1 988
- Bibliographic source:
- Food and Chemicals Toxicology
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Human maximization test
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3,6,10-trimethylundeca-3,5,9-trien-2-one
- EC Number:
- 214-245-8
- EC Name:
- 3,6,10-trimethylundeca-3,5,9-trien-2-one
- Cas Number:
- 1117-41-5
- Molecular formula:
- C14H22O
- IUPAC Name:
- 3,6,10-trimethylundeca-3,5,9-trien-2-one
- Details on test material:
- - Lot/batch No.: 77-8-IFRA-1
Constituent 1
Method
- Type of population:
- general
- Subjects:
- - Number of subjects exposed: 25
- Sex: male, female
- Age: 18+ - Clinical history:
- - healthy
- Route of administration:
- dermal
- Details on study design:
- TYPE OF TEST(S) USED: patch test (epicutaneous test)
ADMINISTRATION
- Type of application: occlusive
- Site: on the forearm or back, pre-treated for 24 hours with 2.5% aqueous sodium lauryl sulfate (SLS) under occlusion
- Vehicle / solvent: petrolatum
- Concentrations: 8%
- Testing/scoring schedule: 5 alternate-day 48 hour periods for induction; following a 10 day rest period, a challenge patch of the test material was applied to a different site for a 48-hour period under occlusion. Prior to challenge, 5 to 10% SLS was applied to test site for one hour before application of test material.
EXAMINATIONS
- Time schedule: the challenge site was read at patch removal and 24 hours thereafter
METHOD
- acc. KLIGMAN,1966
Results and discussion
- Results of examinations:
- NO. OF PERSONS WITH/OUT REACTIONS COMPARED TO STUDY POPULATION
- Number of subjects with positive reactions: 6/25
- Number of subjects with negative reactions: 19/25
Applicant's summary and conclusion
- Conclusions:
- the test substance caused sensitising effects when applied at 8% in petrolatum
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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