Registration Dossier
Registration Dossier
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EC number: 909-122-7 | CAS number: -
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable study report which meets basic scientific principles
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
- Reference Type:
- secondary source
- Title:
- Fragrance raw material monographs
- Author:
- Ford RA
- Year:
- 1 988
- Bibliographic source:
- Food and Chemicals Toxicology, 26(4), 413
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- acute dermal toxicity test
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3,6,10-trimethylundeca-3,5,9-trien-2-one
- EC Number:
- 214-245-8
- EC Name:
- 3,6,10-trimethylundeca-3,5,9-trien-2-one
- Cas Number:
- 1117-41-5
- Molecular formula:
- C14H22O
- IUPAC Name:
- 3,6,10-trimethylundeca-3,5,9-trien-2-one
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- once continously
- Doses:
- 2500, 5000 mg/kg bw
- No. of animals per sex per dose:
- 5000 mg/kg bw: 10 animals; sex not specified
2500 mg/kg bw: 4 animals; sex not specified - Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: at least 9 days
- Necropsy performed: yes
- Other examinations performed: mortality and/or systemic effects
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 500 mg/kg bw
- Mortality:
- 5000 mg/kg bw: 6/10 deaths. 2 deaths occurred on day 2, 2 deaths on day 5, 1 death on day 8 and 1 death on day 9
2500 mg/kg bw: 0/4 deaths - Clinical signs:
- other: 5000 mg/kg bw: diarrhea in 2/10 rabbits and anorexia and lethargy in 1/10 rabbits 2500 mg/kg bw. nonspecific effects
- Gross pathology:
- 5000 mg/kg bw:
- 5/10 rabbits had anogenital exucate
- 6/10 rabbits had dark livers
- 2/10 rabbits had mottled livers
- 1/10 rabbits had dark kidneys
- 4/10 rabbits had mottled kidneys
- 6/10 rabbits had red skin
- 6/10 rabbits had edematous skin
- 4/10 rabbits had thick and hard skin
- 5/10 rabbits had red areas in the intestines
- 2/10 rabbits had bloated intestines
- 1/10 rabbits had a dark spleen
2500 mg/kg bw.
- 2/4 rabbits had anogenital exudate
- 1/4 rabbits had dark areas on the lungs
- 3/4 rabbits had dark livers
- 1/4 rabbits had mottled kidneys
- 4/4 rabbits had thick and hard skin
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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