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Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
24 October 2014 - 27 October 2014
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions) - Method B: Fibre Length and Diameter Distributions
Deviations:
no
Qualifier:
according to
Guideline:
other: (CIPAC MT 170)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
Laser scattering/diffraction
Type of particle tested:
primary particle
Type of distribution:
mass based distribution
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Name of test material (as cited in study report):4-amino-5(ethylsulphonyl)-o-anisic acid
- Physical state:Solid
- Analytical purity: 99.81%
- Lot/batch numberl:MP1032.31
Mass median aerodynamic diameter:
ca. 85.82 µm
Key result
Percentile:
other: d4,3
Mean:
ca. 85.82 µm
Remarks on result:
other: Mass median aerodynamic diameter(De Brouckere Mean Diameter)
No.:
#1
Size:
> 500 µm
Distribution:
0.43 %
Remarks on result:
other: Average of 2 tests
No.:
#2
Size:
>= 300 - <= 500 µm
Distribution:
1.08 %
Remarks on result:
other: Average of 2 tests
No.:
#3
Size:
>= 250 - <= 300 µm
Distribution:
2.51 %
Remarks on result:
other: Average of 2 tests
No.:
#4
Size:
>= 125 - <= 250 µm
Distribution:
15.54 %
Remarks on result:
other: Average of 2 tests
No.:
#5
Size:
>= 75 - <= 125 µm
Distribution:
5.16 %
Remarks on result:
other: Average of 2 tests
No.:
#6
Size:
>= 63 - <= 75 µm
Distribution:
16.19 %
Remarks on result:
other: Average of 2 tests
No.:
#7
Size:
>= 45 - <= 63 µm
Distribution:
30.92 %
Remarks on result:
other: Average of 2 tests
No.:
#8
Size:
< 45 µm
Distribution:
28.19 %
Remarks on result:
other: Average of 2 tests

Table No.1 :Results of particle size distribution

Fraction size

Test no. 1

Test no. 2

Average

[g]

[%]

[g]

[%]

[%]

Over 500μm

0.27

0.28

0.56

0.58

0.43

Between 300-500μm

0.93

0.97

1.13

1.18

1.08

Between 250-300μm

2.51

2.61

2.31

2.41

2.51

Between 125-250μm

15.31

15.93

14.50

15.14

15.54

Between 75-125μm

5.65

5.88

4.25

4.44

5.16

Between 63-75μm

15.53

16.16

15.52

16.21

16.19

Between 45-63μm

29.44

30.64

29.87

31.19

30.92

Under 45 μm

29.44

27.52

27.63

28.85

28.19

Sum of fractions „i” mass Σm1 = 96.08 g

Sum of fractions „i” mass Σm2 = 95.77 g

ΣXi=(Σmi/mc)*100%

The average d4,3 – the mass moment mean (De Brouckere Mean Diameter) calculated

according to:

d4.3= Σxidi

Where:

di : the average of the lower and upper sieves

xi : i - mass fraction

The average equivalent diameter was 85.82 μm.

Conclusions:
The average d4,3, the mass moment mean (De Brouckere Mean Diameter), was determined to be 85.82 μm.
Executive summary:

The determination of particle size distribution was carried out using dry sieve test in accordance with OECD Guideline 110 and CIPAC MT 170.

The average d4,3, the mass moment mean (De Brouckere Mean Diameter), was determined to be 85.82 μm. The obtained particle size distribution was as follows (two replicates): over 500 μm: 0.43 %, fraction 300 - 500 μm: 1.08 %, fraction 250 - 300 μm: 2.51 %, fraction 125 - 250 μm: 15.54 %, fraction 75 - 125 μm: 5.16 %, fraction 63 - 75 μm: 16.19 %, fraction 45 - 63 μm: 30.92 %, under 45 μm: 28.19 %.

Description of key information

Key study: Test method CIPAC MT 170 and OECD 110. GLP study. The average d4,3, the mass moment mean (De Brouckere Mean Diameter), was determined to be 85.82 μm.

Additional information

Key study: The determination of particle size distribution was carried out using dry sieve test in accordance with CIPAC MT 170 and OECD Guideline 110. The average d4,3, the mass moment mean (De Brouckere Mean Diameter), was determined to be 85.82 μm. The obtained particle size distribution was as follows (two replicates): over 500 μm: 0.43 %, fraction 300 - 500 μm: 1.08 %, fraction 250 - 300 μm: 2.51 %, fraction 125 - 250 μm: 15.54 %, fraction 75 - 125 μm: 5.16 %, fraction 63 - 75 μm: 16.19 %, fraction 45 - 63 μm: 30.92 %, under 45 μm: 28.19 %.