Registration Dossier
Registration Dossier
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EC number: 226-733-8 | CAS number: 5459-93-8
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Range-Finding Toxicity Data List VI
- Author:
- Smyth H.F., Carpenter Ch.P., Well C.S., Pozzani U.C., Striegel J.A.,
- Year:
- 1 962
- Bibliographic source:
- American Industrial Hygiene Association Journal
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- no data on test method
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Cyclohexyl(ethyl)amine
- EC Number:
- 226-733-8
- EC Name:
- Cyclohexyl(ethyl)amine
- Cas Number:
- 5459-93-8
- Molecular formula:
- C8H17N
- IUPAC Name:
- N-ethylcyclohexanamine
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- clipped
- Vehicle:
- not specified
- Observation period:
- 24-day
- Number of animals:
- 5
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- other: no data
- Time point:
- 24 h
- Score:
- ca. 6
- Reversibility:
- not specified
- Remarks on result:
- probability of severe irritation
- Irritation parameter:
- erythema score
- Basis:
- other: no data
- Time point:
- 48 h
- Reversibility:
- other: no data
- Remarks on result:
- not measured/tested
- Irritation parameter:
- erythema score
- Basis:
- other: no data
- Time point:
- 72 h
- Reversibility:
- other: no data
- Remarks on result:
- not measured/tested
- Irritation parameter:
- edema score
- Basis:
- other: no data
- Time point:
- 24 h
- Reversibility:
- other: no datat
- Remarks on result:
- other: no data
- Irritation parameter:
- edema score
- Basis:
- other: no data
- Time point:
- 48 h
- Reversibility:
- other: no data
- Remarks on result:
- other: no data
- Irritation parameter:
- edema score
- Basis:
- other: no data
- Time point:
- 72 h
- Reversibility:
- other: no data
- Remarks on result:
- other: no data
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (corrosive) based on GHS criteria
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