Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Long-term toxicity to fish

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
long-term toxicity to fish, other
Remarks:
The estimation is based on EPI Suite, ECOSAR v1.11.
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
The estimation is based on EPI Suite, ECOSAR v1.11. Two models are available, the estimation from the class (Aliphatic Amines-acid) and the Baseline Toxicity (neutral organic structure analysis relationship).
Principles of method if other than guideline:
The estimation is based on ECOSAR v1.11. Two models are available, the estimation from the Class (Aliphatic Amines-acid) and the Baseline Toxicity (neutral organic structure analysis relationship)
GLP compliance:
not specified
Specific details on test material used for the study:
Calculation is based on the structure of N-methyltaurinate
- Name of test material (as cited in study report): Ethanesulfonic acid, 2- (methylamino)-, monosodium salt
Analytical monitoring:
not required
Vehicle:
not specified
Test organisms (species):
no data
Test type:
other: estimation by calculation
Water media type:
not specified
Dose descriptor:
other: ChV
Remarks:
(Aliphatic Amines-acid)
Effect conc.:
145 g/L
Nominal / measured:
not specified
Conc. based on:
not specified
Basis for effect:
other: estimation by calculation
Remarks on result:
ChV (chronic value, QSAR)
Dose descriptor:
other: ChV
Remarks:
(Neutral Organic SAR)
Effect conc.:
163 g/L
Nominal / measured:
not specified
Conc. based on:
not specified
Basis for effect:
other: estimation by calculation
Remarks on result:
ChV (chronic value, QSAR)
Remarks:
Note: Chemical may not be soluble enough to measure this predicted effect
Details on results:
ChV = 10^([log (LOEC x NOEC)]/2)
Validity criteria fulfilled:
not applicable
Conclusions:
The lowest chronic toxicity value for fish estimated by calculation is 145 g/L.
Executive summary:

The lowest calculated chronic toxicity value (ChV) for fish is 145 g/L, which reflects low toxicity. However, the estimation by calculation only provides an approximation and cannot replace empirical studies.

Description of key information

The chronic toxicity value estimated by calculation is 145 g/L for fish.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
145 g/L

Additional information

The lowest calculated chronic toxicity value (ChV) for fish is 145 g/L, which reflects low toxicity. Nevertheless, the estimation by calculation only provides an approximation and cannot replace empirical studies. The EPA recommends that EPI Suite is a screening-level tool and should not be used if acceptable measured values are available. However, empirical studies have not been done, so that we adopt the prediction.