Sodium N-methyltaurinate

Short-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study without detailed documentation

Qualifier:

according to guideline

Guideline:

other: "Regulations Governing Laboratory Certification and Standards of Performance", New Jersey Administrative Code, 7:18

Version / remarks:

as amended July 1984

Deviations:

not specified

GLP compliance:

not specified

Specific details on test material used for the study:

All surfactants were samples of commercially available products. Toxicities of the individual surfactants, their mixtures and reactor effluents were determined by 48h, daily static renewal tests with Mysidopsis bahia (mysids). This marine species was recently introduced as a test organism for monitoring the toxicities of wastewater treatment plant effluents and other discharges to the environment in New Jersey and Florida. Tests were performed according to the procedure in “Regulations Governing Laboratory Certification and Standards of Performance”, New Jersey Administrative Code, 7:18, as amended July 1984. Toxicity results were calculated by a probit method and were reported as a concentration (for untreated products) or a dilution (for effluents) resulting m the death of 50% of the test organisms (LC50).

Analytical monitoring:

not specified

Test organisms (species):

Americamysis bahia (previous name: Mysidopsis bahia)

Test type:

static

Water media type:

saltwater

Total exposure duration:

48 h

Duration:

48 h

Dose descriptor:

LC50

Effect conc.:

12.8 mg/L

Nominal / measured:

meas. (not specified)

Conc. based on:

test mat.

Basis for effect:

mortality

Details on results:

The values were determined during the investigation and are based on a single analysis.

Validity criteria fulfilled:

not specified

Conclusions:

The LC50 (48 h) of methyl oleoyl taurate is 12.8 mg/L for Americamysis bahia.

Executive summary:

The publication reports the toxicity of ethoxylated surfactants, including methyl oleoyl taurate as a reference. The toxicity was determined using Americamysis bahia according to the New Jersey Administrative Code, 7:18 as amended 1984. The LC50 (48 h) of methyl oleoyl taurate is 12.8 mg/L.

Reference 2

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

(Q)SAR

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

accepted calculation method

Justification for type of information:

The estimation is based on EPI Suite, ECOSAR v1.11. Two models are available, the estimation from the class (Aliphatic Amines-acid) and the Baseline Toxicity (neutral organic structure analysis relationship).

Principles of method if other than guideline:

The estimation is based on ECOSAR v1.11. Two models are available, the estimation from the Class (Aliphatic Amines-acid) and the Baseline Toxicity (neutral organic structure analysis relationship)

GLP compliance:

not specified

Specific details on test material used for the study:

Calculation is based on the structure of N-methyltaurinate
- Name of test material (as cited in study report): Ethanesulfonic acid, 2- (methylamino)-, monosodium salt

Analytical monitoring:

not required

Vehicle:

not specified

Test organisms (species):

other: Daphnids

Test type:

other: estimation by calculation

Water media type:

not specified

Total exposure duration:

48 h

Duration:

48 h

Dose descriptor:

LC50

Remarks:

(Aliphatic Amines-acid)

Effect conc.:

29 688.508 mg/L

Nominal / measured:

not specified

Conc. based on:

not specified

Basis for effect:

other: estimation by calculation

Duration:

48 h

Dose descriptor:

LC50

Remarks:

(Neutral Organic SAR)

Effect conc.:

1 030 000 mg/L

Nominal / measured:

not specified

Conc. based on:

not specified

Basis for effect:

other: estimation by calculation

Remarks on result:

other:

Remarks:

Note: Chemical may not be soluble enough to measure this predicted effect.

Validity criteria fulfilled:

not applicable

Conclusions:

The lowest calculated LC50 (48 h) of sodium N-methyltaurinate for daphnia is 29.69 g/L.

Executive summary:

The lowest calculated LC50 (48 h) of sodium N-methyltaurinate for daphnia is 29.69 g/L, which reflects low toxicity. Nevertheless, the estimation by calculation only provides an approximation and cannot replace empirical studies. The EPA recommends that EPI Suite is a screening-level tool and should not be used if acceptable measured values are available.

Description of key information

Using EPI Suite (ECOSAR), an LC50 (48 h) of sodium N-methyltaurinate of 29.69 g/L was calculated for daphnids. Nevertheless, the estimation by calculation only provides an approximation and cannot replace empirical studies. The publication by Patoczka et al. reports an LC50 (48 h) of 12.8 mg/L for read-across substance methyl oleoyl taurate, which was determined according to the New Jersey Administrative Code, 7:18 using Americamysis bahia.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

12.8 mg/L

Additional information

Using EPI Suite (ECOSAR), an LC50 (48 h) of sodium N-methyltaurinate of 29.69 g/L was calculated for daphnids. Nevertheless, the estimation by calculation only provides an approximation and cannot replace empirical studies. The publication by Patoczka et al. reports an LC50 (48 h) of 12.8 mg/L for read-across substance methyl oleoyl taurate, which was determined according to the New Jersey Administrative Code, 7:18 using Americamysis bahia. The empirical value for methyl oleoyl taurate is lower than the estimated value for sodium N-methyltaurinate. The EPA recommends that EPI Suite is a screening-level tool and should not be used if acceptable measured values are available. Nevertheless, both the empirical and estimated values are rather high, so that the studies on the read-across substance support the results of the EPI Suite estimation. Therefore, we conclude that the aquatic toxicity data of methyl oleoyl taurate provide a reasonable measure to estimate the toxicity of sodium N-methyltaurinate on invertebrates.