Registration Dossier
Registration Dossier
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EC number: 225-063-3 | CAS number: 4637-24-5
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
In a Guinea Pig Maximization Test (OECD 406) N, N-Dimethylformamide dimethyl-acetal has shown a sensitizing effect.
After the challenge no skin reactions occurred in the control groups (polyethylene glycol) but 6 of 10 animals in the test group showed a skin sensitising effect. Skin reactions in some animals of the test group at the vehicle treated application site indicate a possible influence of the induction treatment by the test substance on the skin irritation threshold. [BASF, 2003]
Migrated from Short description of key information:
1,1-Dimethoxytrimethylamine showed a sensitizing effect on the skin of the guinea pig in the Maximization Test.
Justification for classification or non-classification
1,1-Dimethoxytrimethylamine is considered to be skin sensitising (EU: R43; GHS: cat.1 H317) according to the criteria of EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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