Registration Dossier
Registration Dossier
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EC number: 229-633-2 | CAS number: 6635-20-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Food flavourings and compounds of related structure. I. Acute oral toxicity
- Author:
- Jenner PM, Hagan EC, Taylor JM, Cook EL and Fitzhugh OG|- Year: 1964|- Title: |- Bibliographic source:
- Year:
- 1 964
- Bibliographic source:
- Food Cosmet Toxicol, 2, 327-343
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 121-33-5'
- IUPAC Name:
- 121-33-5'
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Osborne-Mendel
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Fasting period before study: approx. 18 hrs prior to treatment
- Food consumption: ad libitum
- Water consumption: ad libitum
No more data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- propylene glycol
- Remarks:
- Milk
- Details on oral exposure:
- Concentration in vehicle: 20%
- Doses:
- No data
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- Duration of observation period following administration: 14 days
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 580 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 1 390 - 1 810
- Clinical signs:
- other: coma soon after treatment
- Gross pathology:
- no data
Applicant's summary and conclusion
- Conclusions:
- The LD50 value of Vanillin in rat was observed at a dose leeveel of 1580 mg/kg bw
- Executive summary:
The LD50 value of Vanillin in rat was observed at a dose leeveel of 1580 mg/kg bw
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