Registration Dossier
Registration Dossier
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EC number: 229-633-2 | CAS number: 6635-20-7
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- publication
- Title:
- Problem of the toxicity of vanillin
- Author:
- Makaruk MI
- Year:
- 1 980
- Bibliographic source:
- Gig Sanit, 6, 78-80
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Vanillin
- EC Number:
- 204-465-2
- EC Name:
- Vanillin
- Cas Number:
- 121-33-5
- Molecular formula:
- C8H8O3
- IUPAC Name:
- 1-butoxypropan-2-ol
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- other: undiluted or water
- Controls:
- not specified
- Duration of treatment / exposure:
- no data
- Observation period (in vivo):
- no data
- Number of animals or in vitro replicates:
- no data
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks on result:
- other: caused an eye irritation . there is only eye-watering effect.
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Vannilin as a powder caused an eye irritation on rabbit (due to mechanical action of the needle-shaped crystals). Applied as a saturated aqueous solution, there is only eye-watering effect.
- Executive summary:
Vannilin as a powder caused an eye irritation on rabbit (due to mechanical action of the needle-shaped crystals). Applied as a saturated aqueous solution, there is only eye-watering effect.
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