Registration Dossier
Registration Dossier
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EC number: 229-633-2 | CAS number: 6635-20-7
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
From the EC50 and IGC50 value predicted by the QSAR model for the micro-organism (Tetrahymena Sp), it is concluded that 5-nitrovanillin is expected to be non-toxic to microorganisms within the dose levels mentioned in the two studies
Key value for chemical safety assessment
- EC50 for microorganisms:
- 116.72 mg/L
Additional information
No. of studies were reviewed for toxicity to microorganisms from reliable sources having Klimisch rating 2 and 4.
The summary of the results are presented below :
Sr.No |
Endpoint |
Effect values |
Basis for effects |
Duration |
Species |
CAS Nos. |
Sources |
1 |
EC 50 |
116 mg/L |
Population |
48 hrs. |
Tetrahymena pyriformis |
6635-20-7 |
Predicted data |
2 |
IGC50 |
273 mg/L |
growth |
48hrs. |
Tetrahymena pyriformis |
6635-20-7 |
Predicted data |
3 |
IGC50 |
100 mg/L |
growth inhibition |
15 mins |
Photobacterium phosphoreum |
Read Across 121-33-5 |
Experimental data |
By applying weight of evidence approach to the target substance 2-hydroxy-4-5-methoxybezophenon sulfonic acid and the read across substance in microorganisms (Saccharomyces cerevisiae),the endpoint value was found to vary between EC50 = 116 mg/L in 48 hrs and IGC50 for (Tetrahymena pyriformis) =100mg/L to 273 mg/l in a 48 hrs. on the basis of growth inhibition effect.
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