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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Basic toxicokinetics

Currently viewing:

Administrative data

Endpoint:
basic toxicokinetics
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Hydrolysis of fully esterified alcohols containing from one to eight hydroxyl groups by the lipolytic enzymes of rat pancreatic juice
Author:
Mattson F.H., Volpenhein R.A.
Year:
1972
Bibliographic source:
J Lipid Res 1972, 13, (3), 325-8

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Investigation of the hydrolysis of fully esterified alcohols by the lipolytic enzymes of rat pancreatic juice.
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
Esterified alcohols containing 1 to 8 hydroxyl groups.
IUPAC Name:
Esterified alcohols containing 1 to 8 hydroxyl groups.

Test animals

Species:
other: in vitro study

Results and discussion

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): other:
It is likely that lipases produced by the bile will initiate ester hydrolysis of Propanediol Dicaprylate in the small intestine.