Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Standard health hazard book, recommended in the ECHA guidance on REACH endpoints of May 2008

Data source

Reference
Reference Type:
review article or handbook
Title:
Sax's Dangerous Properties on Industrial Materials
Author:
Lewis R.J.
Year:
1996
Bibliographic source:
9th ed. Volumes 1-3. p. 2519. Van Nostrand Reinhold: New York, NY (USA), 1996

Materials and methods

Test guideline
Guideline:
other: guideline not specified
Principles of method if other than guideline:
Standard health hazard book that is recommended in the ECHA Endpoint Specific Guidance R7a, of May 2008.
Test type:
other: not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Methyl octanoate
EC Number:
203-835-0
EC Name:
Methyl octanoate
Cas Number:
111-11-5
Molecular formula:
C9H18O2
IUPAC Name:
methyl octanoate
Constituent 2
Reference substance name:
Octanoic acid, methyl ester
IUPAC Name:
Octanoic acid, methyl ester

Test animals

Species:
rat

Administration / exposure

Route of administration:
oral: unspecified

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
10 800 mg/kg bw

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Remarks:
Migrated information
Conclusions:
The following LD50 value for Octanoic acid, methyl ester is taken from standard health hazard book, recommended in the ECHA guidance on REACH endpoints of May 2008.
LD50 (oral, rat) = 10800 mg/kg bw