Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-050-0 | CAS number: 91-21-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP, guideline study, available as unpublished report, restrictions in reporting (available report is a summary) but otherwise adequate for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 431 (In Vitro Skin Corrosion: Human Skin Model Test)
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,2,3,4-tetrahydroisoquinoline
- EC Number:
- 202-050-0
- EC Name:
- 1,2,3,4-tetrahydroisoquinoline
- Cas Number:
- 91-21-4
- Molecular formula:
- C9H11N
- IUPAC Name:
- 1,2,3,4-tetrahydroisoquinoline
- Details on test material:
- - Name of the test substance used in the study report: 1,2,3,4-Tetrahydroisoquinoline
- pH (undiluted): ca. 8
- Test substance number: 05/0797-1
- Batch number: LJ 32741/75
Constituent 1
Test animals
- Species:
- other: Human skin model EpiDerm™
Test system
- Vehicle:
- unchanged (no vehicle)
- Duration of treatment / exposure:
- 3 min and 1 h
- Number of animals:
- 2 tissue replicates per treatment
Results and discussion
In vitro
Resultsopen allclose all
- Irritation / corrosion parameter:
- other: other: viability
- Value:
- 47
- Remarks on result:
- other:
- Remarks:
- Time point: 3 minutes. Max. score: 100.0. (migrated information)
- Irritation / corrosion parameter:
- other: other: viability
- Value:
- 14
- Remarks on result:
- other:
- Remarks:
- Time point: 1 hour. Max. score: 100.0. (migrated information)
In vivo
- Irritant / corrosive response data:
- Viability results (% relative to negative control):
- test material: 47% and 14% upon exposure for 3 minutes and 1 hour, respectively.
- positive control: 20% and 9% upon exposure for 3 minutes and 1 hour, respectively.
Evaluation: corrosive
The test method does not yet allow for the dffferentlation of severity of the effect The results however indicate moderate corrosivity (EC: R 34, GHS: subcategory 1B). For final assignment of a risk phrase at present, further evidence or results from an in vlvo study would be needed.
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
