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EC number: 689-986-7 | CAS number: 1742-79-6
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15 May 2013 to 17 March 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Conducted according to current test guidelines and GLP compliant
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- 2-oxo-1,2-dihydropyridin-1-yl acetate
- EC Number:
- 689-986-7
- Cas Number:
- 1742-79-6
- Molecular formula:
- C7H7NO3
- IUPAC Name:
- 2-oxo-1,2-dihydropyridin-1-yl acetate
- Reference substance name:
- 1742-78-6
- IUPAC Name:
- 1742-78-6
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- Name: Oxypyrion acetate
CAS Number: 1742-78-6
Batch number: 14058400
Purity: 97.83%
Date of arrival: 22 April 2013
Expiry date: 30 November 2013
Storage conditions: Refrigerated (2 to 8°C)
Constituent 1
Constituent 2
Results and discussion
Partition coefficientopen allclose all
- Type:
- log Pow
- Partition coefficient:
- -1.56
- Temp.:
- 25 °C
- Remarks on result:
- other: Peak 1 (0,32%)
- Type:
- log Pow
- Partition coefficient:
- -0.5
- Temp.:
- 25 °C
- Remarks on result:
- other: Peak 2 (99,69%)
- Details on results:
- There were two chromatographic peaks attributable to Oxypyrion acetate, under the guideline test conditions.
The two Oxypyrion acetate peaks had retention times greater than that of dead time marker, formamide, but less than that of the lowest standard, 2-butanone.
As the retention time of the Oxypyrion acetate was outside the calibration range the Log Pow values are therefore extrapolated values.
Test 1: Peak 1: Log Pow = -1,62 (0,24 %); Peak 2: Log Pow = -0,49 (99,76 %)
Test 2: Peak 1: Log Pow = -1,50 (0,39 %); Peak 2: Log Pow = -0,50 (99,61 %)
Mean: Peak 1: Log Pow = -1,56 (0,32 %); Peak 2: Log Pow = -0,50 (99,69 %)
Applicant's summary and conclusion
- Conclusions:
- There were two chromatographic peaks attributable to Oxypyrion acetate, under the guideline test conditions.
The mean partition coefficient values (log Pow) determined were -1,56 (0,32 %) for Peak 1 and -0,50 (99,69 %) for Peak 2.
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