Registration Dossier
Registration Dossier
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EC number: 201-810-9 | CAS number: 88-21-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Acute toxicity data for cas no.121-57-3
- Author:
- Patty, F. A.
- Year:
- 1 967
- Bibliographic source:
- Industrial Hygiene and Toxicology 1967, 2, Interscience Publishers, New York, NY, USA.
- Reference Type:
- review article or handbook
- Title:
- DOSE: S138
- Author:
- RSC Publishing
- Year:
- 2 011
- Bibliographic source:
- Dictionary of Substances and their effects (DOSE): Patty, F. A. Industrial Hygiene and Toxicology 1967, 2, Interscience Publishers, New York, NY, USA.
Materials and methods
- Principles of method if other than guideline:
- The acute toxicity study was conducted to evaluate the toxic effects of administration of sulphanilic acid to mouse by the oral route.
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- Sulphanilic acid
- EC Number:
- 204-482-5
- EC Name:
- Sulphanilic acid
- Cas Number:
- 121-57-3
- Molecular formula:
- C6H7NO3S
- IUPAC Name:
- 4-aminobenzenesulfonic acid
- Details on test material:
- - Name of test material (as cited in study report):sulphanilic acid
- Substance type:Organic
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 3 200 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: sulphanilic acid does not exhibits acute toxicity by the oral route.
- Mortality:
- Lethal dose ; 50 percent kill
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral median lethal dose (LD50) of sulphanilic acid in mouse was found to be >3200 mg/kg of body weight. Acute toxicity of sulphanilic acid to mouse indicates that sulphanilic acid does not exhibits acute toxicity by the oral route.
- Executive summary:
The acute oral median lethal dose (LD50) of sulphanilic acid in mouse was found to be >3200 mg/kg of body weight. Acute toxicity of sulphanilic acid to mouse indicates that sulphanilic acid does not exhibits acute toxicity by the oral route.
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