Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 500-036-1 | CAS number: 25214-70-4
Endpoint summary
Administrative data
Description of key information
There is available information in humans that the substance should be classified for skin sensitisation. A skin patch test study in humans is available that reports a positive result and therefore a study is not required (Morris et al, 1954).
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Additional information:
Justification on read-across of data for the 4,4´-isomer of MDA for oligomeric MDA in the scope of REACH is documented in IUCLID Toxicological information and described in sections 5.1 and 5.11 of the CSR.
A study with patch tests in volunteers revealed a skin sensitizing potential of MDA in man (Morris et al, 1954)
The following information is taken into account for any hazard / risk assessment:
There is convincing evidence that MDA is a skin sensitizer in humans. MDA also demonstrates cross-reactions to para-groups. Based on human data MDA is already classified as "sensitising" and labelled with R43 (may cause sensitisation by skin contact). (From the EU Risk assessment on MDA published 2001)
Migrated from Short description of key information:
Value used for CSA: sensitising
Justification for classification or non-classification
According to regulation 1272/2008/EC, MDA is classified as skin sensitising, H317: may cause allergic skin reaction.
MDA is classified according to annex I, directive 67/548/EC: R43 -May cause sensitisation by skin contact.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
