Registration Dossier
Registration Dossier
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EC number: 500-036-1 | CAS number: 25214-70-4
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Yokohama Laboratories (Mitsubishi 2002) have provided a fully detailed high quality report.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.005 mg/L
Additional information
A full discussion on the justification on read-across of data for the 4,4´-isomer of MDA for oligomeric MDA in the scope of REACH is presented in section 7.6 of this CSR.
This study was carried out according to GLP (certificate included) and in which all described parameters are closely comparable to the standard OECD Guideline 211 method. The 21d NOEC value of 0.00525 mg/l indicates that MDA is toxic to invertebrates. The results confirm that for 4,4'-MDA invertebrates are the most sensitive species of the three trophic levels of the base set (fish, daphnia and algae). Therefore, this NOEC value may be used to derive a PNECaqua value.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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