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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
21 May - 29 May 1990
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Although the study is well described, it is not carried out according to a guideline or GLP.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1990
Report date:
1990

Materials and methods

Principles of method if other than guideline:
The partition coefficient Pow is defined as the ratio of the equilibrium concentrations (c) of a dissolved substance in a two-phase system consisting of two largely immiscible solvents. In the case of n-octanol and water:

Pow = c(n-octanol)/ c(water)

For TPAB an estimation of the partition coefficient was performed, using the ratio of the maximal solubility in n-octanol (saturated with water) and water (saturated with n-octanol).
GLP compliance:
no
Type of method:
other: The partition coefficient was estimated as the quotient of the maximal solubility of TPAB in n-octanol (saturated with water) and water (saturated with n-octanol).
Partition coefficient type:
octanol-water

Test material

Constituent 1
Reference substance name:
TPAB
IUPAC Name:
TPAB
Test material form:
solid: crystalline
Details on test material:
- Name of test material (as cited in study report): TPAB
- Substance type: White crystalline solid
- Physical state: solid
- Analytical purity: 99.9%
- Lot/batch No.: T 90-4
- Storage condition of test material: In the original container at room temperature, dry and in the dark.

Study design

Analytical method:
photometric method

Results and discussion

Partition coefficientopen allclose all
Type:
Pow
Partition coefficient:
< 0.5
Temp.:
20 °C
Remarks on result:
other: Based on the maximal solubility in n-octanol (saturated with Milli-Q water) and Milli-Q water (saturated with n-octanol)
Type:
log Pow
Partition coefficient:
< -0.3
Temp.:
20 °C
Remarks on result:
other: Based on the maximal solubility in n-octanol (saturated with Milli-Q water) and Milli-Q water (saturated with n-octanol)
Details on results:
Solubility of TPAB in Milli-Q water (saturated with n-octanol):
No solid particles were observed visually in the clear, almost colourless formulations. From this, it was concluded that the solubility of TPAB in water (saturated with n-octanol) was > 1 g/mL. Analysis of the water samples of both measurements confirmed this observation. The solubility of TPAB in Milli-Q water (saturated with n-octanol) was determined to be 1.2 and 1.1 g/mL for the first and second measurement, respectively. Therefore, it was concluded that the water solubility of TPAB was > 1 g/mL.

Solubility of TPAB in n-octanol (saturated with Milli-Q water):
Visual observations revealed that not all the test substance was dissolved after the stirring period. The solubility of TPAB in n-octanol (saturated with Milli-Q water) was determined to be 0.47 g/mL and 0.45 g/mL for the first and second measurement, respectively. Hence, the n-octanol solubility of TPAB was calculated to be 0.5 g/mL as a mean value of both measurements.

Applicant's summary and conclusion

Conclusions:
The Log Pow was < -0.3.
Executive summary:

The partition coefficient was estimated as the quotient of the maximal solubility of TPAB in n-octanol (saturated with water) and water (saturated with n-octanol). This resulted in a Log Pow < -0.3.