Registration Dossier
Registration Dossier
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EC number: 217-727-6 | CAS number: 1941-30-6
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
In a 48-h acute toxicity study carried out according to OECD 202 and GLP principles, water fleas (Daphia magna) were exposed under static conditions to tetra-n-propylammonium bromide at nominal concentrations of 0 (blank), 0.1, 1, 10, 100 and 1000 mg/L in a range finding test, followed by a final test with 0(blank), 32, 52; 100; 180; 320; 560 and 1000 mg/L. Nominal test concentrations were not confirmed by analytical measurements during the test. The water stability of test substance under test conditions was guaranteed only during 4h, which is not ideal since the duration of the test is 48h. However, according to analytical data that was provided by the sponsor for the short term toxicity with fish, it was demonstrated by analytical measurements that the test substance remained stable for a period of 96h, which inidcates that the test substance was also stable during the Daphnia study. The nominal 48h-EC50 of TPAB to Dapnia magna was 278 mg/L and the nominal NOEC was 100 mg/L.
Since the nominal concentrations were not confirmed by analytical measurements, the present study is classified as reliable with restrictions.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 278 mg/L
Additional information
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