Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP Compliance

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Report date:
1991

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: 84/449/EWG, B.1
GLP compliance:
yes
Test type:
other: standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
2-benzyl-2-dimethylamino-4'-morpholinobutyrophenone
EC Number:
404-360-3
EC Name:
2-benzyl-2-dimethylamino-4'-morpholinobutyrophenone
Cas Number:
119313-12-1
Molecular formula:
C23H30N2O2
IUPAC Name:
2-benzyl-2-(dimethylamino)-1-[4-(morpholin-4-yl)phenyl]butan-1-one

Test animals

Species:
other: rat,TiF: RAlf (SPF)
Sex:
male/female

Administration / exposure

Route of administration:
oral: drinking water
Vehicle:
other: distilled water containing 0/5% carboxymethylcellulose and 0.1% Polysorbate 80

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Mortality:
Male : 2000mg/kg bw ; number of animals: 5; Number of deaths: 0.
Male : 5000mg/kg bw ; number of animals: 5; Number of deaths: 0.
Female : 2000mg/kg bw ; number of animals: 5; Number of deaths: 0.
Female : 5000mg/kg bw ; number of animals: 5; Number of deaths: 0.
Clinical signs:
other: Unspcific symptoms of intoxication, reversible with 10 days in all animals
Gross pathology:
Effects on Organs: no findings

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Not conisdered harmful.
Executive summary:

Due to the lack of information provided by ECHA, it is difficult to assess this end point fully. It appears from information provided that the substance has low toxicity.