Registration Dossier
Registration Dossier
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EC number: 404-360-3 | CAS number: 119313-12-1 CG 25-369; IRGACURE 369; TK 11-319
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP Compliance
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 84/449/EWG, C.2
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2-benzyl-2-dimethylamino-4'-morpholinobutyrophenone
- EC Number:
- 404-360-3
- EC Name:
- 2-benzyl-2-dimethylamino-4'-morpholinobutyrophenone
- Cas Number:
- 119313-12-1
- Molecular formula:
- C23H30N2O2
- IUPAC Name:
- 2-benzyl-2-(dimethylamino)-1-[4-(morpholin-4-yl)phenyl]butan-1-one
- Details on test material:
- 25ml standard solution containing 2.5g test substance and 80mg alkylphenol-polyglycolether in acetone.
Constituent 1
Test organisms
- Test organisms (species):
- other aquatic crustacea: DM
Test conditions
- Hardness:
- 240mgCaCO3/L
Results and discussion
Effect concentrations
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.8 mg/L
- Details on results:
- % concentration loss over test: 89 to 96
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- Met criteria set by CA for notification
- Conclusions:
- Very toxic to aquatic organisms
- Executive summary:
Only limited data has been provided by ECHA, but it is apparent that the substance was poorly stable under the conditions of the study, despite using semi-static method for renewal of test media. It is known that the substance is very unstable in light and it can be assumed that the toxicity was as a result of exposure to one or more of the abiotic metabolites. This method of exposure is considered valid for risk assessment.
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