Registration Dossier
Registration Dossier
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EC number: 215-153-0 | CAS number: 1307-86-4
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Relevant and reliable data that could be used for PNEC derivation for long-term toxicity for freshwater fish were retrieved for 3 different species. The EC10s ranged from 351.4 µg Co/L for Pimephales promelas to 2,171 µg Co/L for the Oncorhynchus mykiss. Relevant and reliable data that could be used for PNEC derivation for long-term toxicity for marine fish were retrieved for one species. The EC10 value for the sheepshead minnow, Cyprinodon variegatus was 31,802 µg Co/L . Test results were obtained in experiments that followed international accepted guidance and were based on measured levels of dissolved cobalt as cobalt dichloride.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 351.4 µg/L
Marine water fish
Marine water fish
- Effect concentration:
- 31 802 µg/L
Additional information
Freshwater:
High quality NOEC/L(E)C10 values for chronic toxicity to freshwater fish are based on three fish species, Pimephales promelas, Danio rerio,and Oncorhynchus mykiss. The NOEC/L(E)C10 values for fish range from 351.4 µg Co/L for Pimephales promelas (CDI 2009b) to 2,171 µg Co/L for the Oncorhynchus mykiss (CDI 2009c). The following table indicates those NOEC or EC10 values that have been carried forward for the HC5 and PNEC derivation:
NOEC or EC10 values for fish that have been carried forward for the freshwater HC5/PNEC derivation.
| Key Study (freshwater fish) | Selected values for the most sensitive endpoints used for derivation of the freshwater HC5 | ||
| Species | Endpoint | Value (µg Co/L) |
|
CDI 2009d |
Danio rerio |
Mortality |
1,085 |
CDI 2009b |
Pimephales promelas |
Biomass |
351.4 |
CDI 2009c |
Oncorhynchus mykiss |
Biomass |
2,171 |
Marine:
Chronic toxicity values are reported for one marine fish species. The EC10 value for the sheepshead minnow, Cyprinodon variegatus was 31,802 µg Co/L (CDI 2010c).
NOEC or EC10 values for fish that have been carried forward for the marine HC5/PNEC derivation.
| Key Study (marine fish) | Selected values for the most sensitive endpoints used for the derivation of the marine HC5 | ||||
| Species | Endpoint | Value (µgCo/L) |
|||
| CDI 2010c | Cyprinodon variegatus | Biomass | 31,802 | ||
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