Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 215-153-0 | CAS number: 1307-86-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- other: Any kind of reliability rating is not considered to be applicable, since human epidemiological studies, field studies and case reports are not conducted/reported according to standardised guidelines
- Rationale for reliability incl. deficiencies:
- other: reasonably well described case report with minor reporting deficiencies
Data source
Reference
- Reference Type:
- publication
- Title:
- Asthme aux sels de cobalt
- Author:
- Pilliere F et al.
- Year:
- 1 990
- Bibliographic source:
- Arch. Mal. Prof. 51, 413-417
Materials and methods
- Type of sensitisation studied:
- respiratory
- Study type:
- case report
- Principles of method if other than guideline:
- The reference is a a single case report of a 19 year old worker sensitised to cobalt resinate
- GLP compliance:
- no
Test material
- Reference substance name:
- cobalt resinate
- IUPAC Name:
- cobalt resinate
Constituent 1
Method
- Type of population:
- occupational
- Ethical approval:
- not specified
- Subjects:
- - Number of subjects exposed: 1
- Sex: male
- Age: 19
- Race: no data
- Demographic information: no data - Clinical history:
- For the past 6 months, the patient has worked in cobalt salt production. He was assigned to the bagging of cobalt resinate powder, protected by a dust mask.
Two weeks after starting this work he developed a cough and difficulty breathing, occurring at the end of the work shift. From the third week, symptoms included one-to-two typical asthma attacks per week. These attacks would only start after the patient arrived home, and were not accompanied by other respiratory, ocular or cutaneous allergic events. All respiratory symptoms disappeared during the weekends. - Controls:
- No controls were used.
- Route of administration:
- inhalation
- Details on study design:
- TYPE AND DETAILS OF TEST(S) USED
- Skin prick test: conducted on other respiratory allergens (house dust, mites, pollens)
- Bronchial challenge test: with cobalt resinate
- Other immunological tests: total IgE
- Lung function measurements: baseline pulmonary function tests
Results and discussion
- Results of examinations:
- Clinical examination revealed no anomalies other than sibilant rales in both lung fields. Subsequent examinations, performed after exposure had stopped, auscultation of the lungs was normal. The additional respiratory symptoms also disappeared with the cessation of work.
Haematology did not show hypereosinophilia, total IgE was only slightly elevated (125kU/l : N<100); skin testing for respiratory allergens (house dust, mites, pollens) were negative.
Baseline pulmonary function tests were normal. There was, however, bronchial hyperactivity, the preliminary acetylcholine dose was 400µg. This functional profile is suggestive of an early asthmatic illness.
An initial exposure test was conducted in a hospital setting using cobalt resinate. A 5-minute exposure to the powder immediately provoked cough and respiratory irritation; the FEV1 dropped 26% from its initial value. This bronchospasm spontaneously corrected in a few minutes, however a delayed reaction then appeared at the fourth hour. This time the spontaneous return to normal commenced in the ninth hour. This initial test allowed the diagnosis of occupational asthma due to cobalt resinate. The assessment continued with exposure tests to cobalt stearate and to tall oil resin.
Cobalt stearate was chosen because it is one of the less irritating cobalt salts. Grinding and manipulation of the powder over 20 minutes was followed by a drop in the FEV1 starting at the third hour, culminating by the sixth hour (-30%), and accompanied by dyspnoea. The recovery was spontaneous over several hours.
Grinding and manipulation of tall oil resin over 20 minutes only induced a brief, spontaneously disappearing irritative response at the end of the exposure. Lung function testing was unchanged over a 24-hour period.
Applicant's summary and conclusion
- Conclusions:
- In a single-case study on occupational exposure to cobalt resinate via inhalation, precipitated a positive finding in a bronchio-constriction test (decrease of FEV1 by ca. 30%).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
