Reaction products of ricinoleic acid with 2-aminoethanol and maleic acid and sodium hydrogensulfite

Solubility in organic solvents / fat solubility

Link to relevant study record(s)

Reference

Endpoint:

solubility in organic solvents / fat solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2013

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

other: OECD 105

Principles of method if other than guideline:

taking n-octanol as solvent.

GLP compliance:

no

Key result

Medium:

n-octanol

Solubility:

< 50 mg/L

Temp.:

20 °C

Test substance stable:

yes

Following results were obtained: 

 

Incubation time (h)	Weighted sample (mg)	Concentration (mg/L)
24	30.46	1.6
48	30.30	2.6
72	30.19	12.1

 

 

Nominal saturation concentration (g/L): about 0.3 g/L

 

The result given in the table were approved by independent determinations in duplicate.

 

After a measurement period of 72 hours no concentration plateau was reached. So the data of the preliminary tests were consulted in order to evaluate the solubility of the sample in n-Octanol.

The samples were weighted into vials and n-Octanol was added according the table. Then it was stirred for 30 min at room temperature and visually examinated. After 24 h at room temperature and no stirring the optical evaluation was performed.

 

 

Weighted sample (mg)	n-Octanol (mL)	Concentration (mg/L)	Optical Evaluation
0.7	30	23	clear solution
0.6	20	30	clear solution
0.67	10	67	cloudy solution
0.75	4	187	cloudy solution

 

Based on the results the n-Octanol solubility of the test item can be estimated to be < 50 mg/L.

 

Conclusions:

The octanol solubility at 20°C was determined to be < 50 mg/L.

Executive summary:

In the non-GLP Kllimisch 1 study from Frischmann (2013) the octanol solubility of Reaction products of ricinoleic acid with 2-aminoethanol and maleic acid and sodium hydrogensulfite was determined following the method as outlined in the OECD 105. Instead of water, octanol was used. The octanol solubility at 20°C was determined to be < 50 mg/L.

This value is considered relevant an reliable for the risk assessment. For the risk assessment, the n-octanol solubility of 50 mg/L will be used.

Description of key information

n-octanol solubility (20°C):  50 mg/L 

Additional information

In the non-GLP Kllimisch 1 study from Frischmann (2013) the octanol solubility of Reaction products of ricinoleic acid with 2-aminoethanol and maleic acid and sodium hydrogensulfitewas determined following the method as outlined in the OECD 105. Instead of water, octanol was used. The octanol solubility at 20°C was determined to be < 50 mg/L.

This value is considered relevant an reliable for the risk assessment. For the risk assessment, the n-octanol solubility of 50 mg/L will be used.