Registration Dossier
Registration Dossier
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EC number: 231-306-4 | CAS number: 7491-02-3
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects up to the limit of water solubility (2 mg/L in aqua dest) for Danio rerio (ISO 7346/1), read across
Key value for chemical safety assessment
Additional information
Since no studies investigating the short-term toxicity of Diisopropyl sebacate (CAS 7491-03-2) to freshwater fish are available for this endpoint, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 Grouping of substances, a read-across to the structurally related category member Dibutyl sebacate (CAS 109-43-3) was conducted.Further justification is given within the endpoint summary 6.1 and within the category justification section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance within this category was used.
The study with Dibutyl sebacate (CAS 109-43-3) was conducted according to ISO guideline 7346/1 under semi-static conditions; however, the study was not performed under GLP. The test material was directly added to the test vessels in order to obtain nominal test concentrations of 1000, 3000 and 10,000 mg/L. No mortality of Brachydanio rerio was observed in any treatment during the test period of 96 hours. Hence, the 96 h-LC50 is determined to be >10000 mg/L based on the nominal test concentrations.
Due to the structural and property similarities with the tested category member Dibutyl sebacate (CAS 109-43-3) this result is also applicable to read across to Diisopropyl sebacate (CAS 7491-03-2).
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