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EC number: 947-389-1 | CAS number: -
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
Significant accumulation of Mochon, roh (EC 947-389-1) in organisms is not to be expected.
Key value for chemical safety assessment
Additional information
QSAR-disclaimer:
In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met. Furthermore according to Article 25 of the same Regulation testing on vertebrate animals shall be undertaken only as a last resort.
According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.
For the assessment of reaction mass of 4-methoxyphenol and 4-methoxy-cyclohexanone and 4-methoxy-cyclohexanol (EC 947-389-1; Mochon roh) (Q)SAR results were used for the estimation of the bioaccumulation factor. The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint(s) sufficiently covered and suitable for risk assessment.
Therefore, and for reasons of animal welfare, further experimental studies on aquatic bioaccumulation are not provided.
Assessment:
No experimental data on the bioaccumulation potential of reaction mass of 4-methoxyphenol and 4-methoxy-cyclohexanone and 4-methoxy-cyclohexanol (EC 947-389-1; Mochon roh) are available.
In accordance with column 2 of REACH Annex IX, a bioaccumulation study does not need to be conducted since the constituent substances (CAS 13482-23-0, CAS 18068-06-9 and CAS 150-76-5) have log Kow values of less or equal than 3.
In order to assess the bioaccumulation potential of the substance, the BCF was additionally calculated with several estimation models for the three representative constituents (Table 1).
Table 1.
BCF (L/kg) |
CAS 13482-23-0 |
CAS 18068-06-9 |
CAS 150-76-5 |
BCFBAF v3.01 (EPI Suite v4.11): Meylan et al. (1997/1999) |
3.2 |
3.2 |
5.1 |
BCFBAF v3.01 (EPI Suite v4.11): Arnot-GobasBCF, upper trophic, incl. biotransformation |
1 |
1.4 |
3.9* |
BCFBAF v3.01 (EPI Suite v4.11): Arnot-GobasBCF, upper trophic, excl. biotransformation |
1.1 |
1.6 |
5.0* |
US EPA T.E.S.T. v4.2.1: Bioaccumulation: Consensus method |
6.3 |
6.7 |
12.2 |
The substances were within the AD of all estimations models. However, the results using Arnot &Gobas (2003) method may be less acurate for CAS 150 -76 -5 as the substances's property to appreciably ionize at physiological pH.
Since there are no experimental data on the bioaccumulation of the Mochon, roh (EC 947 -389 -1), the data from a read-across were used to estimate the bioaccumulation potential of the substance. Based on a weight-of-evidence approach, significant accumulation in organisms is not to be expected.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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