reaction mass of 4-methoxyphenol and 4-methoxy-cyclohexanone and 4-methoxy-cyclohexanol

Exposure related observations in humans: other data

Administrative data

Endpoint:

exposure-related observations in humans: other data

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Meets generally accepted scientific standards, well documented and acceptable for assessment

Data source

Reference

Reference Type:

publication

Title:

From chemosensory thresholds to whole body exposures - experimental approaches evaluating chemosensory effects of chemicals

Author:

van Thriel C, Schäper M, Kiesswetter E, Kleinbeck S, Juran S, Blaszkewicz M, Fricke H-H, Altmann L, Berresheim H, Brüning T

Year:

2006

Bibliographic source:

Int. Arch. Occup. Environ. Health 79: 308-321

Materials and methods

Endpoint addressed:

respiratory irritation

Principles of method if other than guideline:

In an experiment performed with a collective of 72 humans the odor threshold and the lateralization threshold of cyclohexanol was determined.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Cyclohexanol

EC Number:

203-630-6

EC Name:

Cyclohexanol

Method

Ethical approval:

confirmed, but no further information available

Details on study design:

In an experiment performed with a collective of 72 humans the odor threshold and the lateralization threshold of cyclohexanol was determined
Subjects Institute 1
Group 1 - 18 females between 18 - 35 years
Group 2 - 18 males between 18 - 35 years
Group 3 - 18 females > 45 years
Group 4 - 18 males > 45 years

Subjects Institute 2
Group 1 - 18 females between 18 - 35 years
Group 2 - 18 males between 18 - 35 years
Group 3 - 18 females > 45 years
Group 4 - 18 males > 45 years


Study protocol:
At the Institute 1 the chemosensory thresholds of nine substances (not cyclohexanol) were measrued in three consecutive sessions.
At the Institute 2 six substances (including cyclohexanol) were investigated (Both investigations were performed using three substances within one session, separated by breaks of at least 15 mins).
Assessment of chemosensory thresholds
The psychophysical procedure used has been proposed by Dalton (Dalton et a. 2000) to assess odor and lateralization thresholds in a standardized way. In two separate runs, the odor threshold and the nasal lateralization thresholds were measured.

Exposure assessment:

measured

Results and discussion

Results:

The median of the cyclohexanol odor threshold obtained in step 1 was 0.49 ppm; the median of the lateralization threshold was 427 ppm (converted into 1,77 mg/l).