Registration Dossier
Registration Dossier
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EC number: 944-572-8 | CAS number: -
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
NOEC (91d) = 0.006 mg/L (measured) for Oncorhynchus mykiss (ASTM E 1241-05, read across)
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 0.006 mg/L
Additional information
Since no study assessing the long-term toxicity of 5-[C11-12 (branched) alkyl]-2-hydroxybenzaldehyde oxime to fish is available, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 Grouping of substances, a read-across to Phenol, 4-nonyl-,branched (CAS 84852-15-3) was conducted, which is structurally similar to the main component of the substance. The analogue justification document is attached to chapter 13.
The available study investigated the long-term toxicity of 4-nonylphenol to early life stage of rainbow trout (Oncorhynchus mykiss) under flow through conditions (Spehar et al. 2010). The study was performed according to ASTM guideline E 1241-05 over an exposure time of 91 days. 100 fertilized eggs per test concentration were exposed to measured concentrations of 6.0, 10.3, 23.1, 53.0 and 114 µg/L 4-nonylphenol. The test system was maintained at ~ 11 ºC and a pH of 6.97. Mean percent hatch of any test concentration was not significantly different from controls. Time to hatch was 39 ± 5 days with swim-up at approximately at day 45. The most sensitive end point was growth. The 91-day NOEC value, based on sublethal effects (growth measured by mean standard length, wet weight and dry weight) is determined to be 6.0 µg/L.
Based on the reasons given above this value is considered to be sufficiently conservative to be used for PNEC derivation of 5-[C11-12 (branched) alkyl]-2-hydroxybenzaldehyde oxime.
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