Registration Dossier
Registration Dossier
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EC number: 293-003-3 | CAS number: 91031-98-0
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No effects observed up to the limit of water solubility for Daphnia magna (OECD 202 part 2, read across)
Key value for chemical safety assessment
Additional information
Since no study assessing the long-term toxicity of Fatty acids, C8 -10, octyl esters (CAS 91031-98-0) to aquatic invertebrates is available, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 Grouping of substances, a read-across to the structurally similar substance isopropyl myristate (CAS 110-27-0) was conducted. Further justification of the read-across approach is given within the endpoint summary 6.1 and the analogue justification document in section 13.
The key study with isopropyl myristate (CAS 110-27-0) was performed according to the OECD guideline 202 part 2 (similar to OECD 211) and GLP (Wierich, 1995). The test organism Daphnia magna was exposed to the test substance in a semi-static system for 21 days, at loading rates of 0.1 and 100 mg/L. The substance did not have any effect on the on survival and reproduction of the test organisms at the tested loading rates. Thus the 21d-EL50 is determined to be > 100 mg/L and the 21d-NOEL is determined to be ≥ 100 mg/L.
Based on the above mentioned results, and due to the structural and profile similarities of the target and the source substance, it can be concluded that no toxicological long-term effects on aquatic invertebrates are expected up to the limit of water solubility for Fatty acids, C8 -10, octyl esters (CAS 91031-98-0).
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