Registration Dossier
Registration Dossier
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EC number: 221-359-1 | CAS number: 3077-12-1
Endpoint summary
Administrative data
Description of key information
Additional information
Only limited data is available for the environmental fate of the target substance N,N-Dihydroxyethyl-p-toluidine (CAS 3077-12-1). Therefore, read-across was performed to the structurally and chemically closely related source substance2-[(2-hydroxyethyl)(4-methylphenyl)amino]ethan-1-ol(EC 911-490-9) in accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5 in order to meet the standard information requirements laid down in Annex VIII of the Regulation.
The source substance is a multi-constituent, which is predominantly composed of the target substance (2,2’-[4-methylphenyl)imino] diethanol, CAS 3077-12-1) itself as well as a second component named (2-{[(2-(2-hydroxyethoxy)ethyl](4-methylphenyl)amino)ethanol, CAS 878391-30-1). The second component only differs in the composition of one side chain, which additionally contains two C-atoms and an ether group. Based on the high degree of structural and chemical similarity and the fact that the source substance principally consists of the target molecule, the target substance is expected to exhibit a similar environmental fate profile as the selected source substance. The structural differences of the second constituent of the source substance are not expected to significantly affect the overall environmental fate profile. Therefore, the source substance is considered a suitable representative for the prediction of the environmental fate and pathways of the target substance by extrapolation from source data, in accordance with Annex XI, item 1.5, of Regulation (EC) No 1907/2006. A detailed read-across approach justification is provided in IUCLID section 13.
The target substance is a mono-constituent substance characterized by high water solubility (19.8 g/L 20 °C, pH 6.91, OECD 105), low vapour pressure (0.000447 Pa at 25°C, MPBWIN v1.43), and a low partition coefficient (2.0 at 35 °C and neutral pH, OECD 117, HPLC method). The adsorption potential (log Koc) is also expected to be low, since it is related to the octanol water partition coefficient, which is supported by the low log Koc value reported for the source substance (2.22 – 2.44). Based on these physico-chemical properties, the substance is expected to preferentially distribute into the water compartment if released to the environment and could moderately also distribute into the soil and sediment compartment. Furthermore, the substance is not rapidly biodegradable by microorganisms of activated sludge (1.5% in 28 d, CO2 evolution, OECD 301 B).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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