Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 221-359-1 | CAS number: 3077-12-1
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 27 Nov 2012 - 01 May 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - HPLC Method)
- Version / remarks:
- 2008
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- 2004
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7570 (Partition Coefficient, n-octanol / H2O, Estimation by Liquid Chromatography)
- Version / remarks:
- 1996
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- 2
- Temp.:
- 35 °C
- pH:
- 7
Reference
Calculation Method
The Pow and log Pow was calculated using the Rekker calculation method
Pow: 3.5x10^1
Log Pow = 1.55
HPLC method
In the chromatogram of the test solution, two major peaks and several small test substance peaks were observed.
The equation of the regression line was: log k’ = 0.613 × log Pow – 0.589 (r = 0.998, n = 12).
The log Pow of the two main components at neutral pH was:
2,2’-[(4-methylphenyl)imino] Diethanol, log Pow = 2.0
2-{[2-(2-hydroxyethoxy)ethyl](4-methylphenyl)amino}ethanol, log Pow = 2.3
Conclusion
The partition coefficient was determined for the multi-constituent substance Reaction mass of 2,2'-[(4-methylphenyl)imino]bisethanol and Ethanol 2-[[2-(2-hydroxyethoxy)ethyl](4-methylphenyl)amino]-
It was possible to distinguish between the two constituents in the HPLC due to the difference in molecular weights.
The log Pow of N,N-dihydroxyethyl-p-toluidine was determined to be equal to 2.0.
Description of key information
log Pow = 2.0 at 35 °C and neutral pH (HPLC method, OECD 117)
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 2
- at the temperature of:
- 35 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
