Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
pH
Type of information:
calculation (if not (Q)SAR)
Remarks:
calculation of pH based on pKs values
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Remarks:
The pH values at different concentrations were calculated from the pKa value of the handbook and is based on the Henderson-Hasselbalch equation
Justification for type of information:
Handbook data are considered to be from a trusted source acc. to "ECHA, Guidance on information requirements and chemical safety assessment – Chapter R.7a: Endpoint specific guidance".

Data source

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The pH values at different concentrations were calculated from the pKa value of the handbook and is based on the Henderson-Hasselbalch equation.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Pyruvic acid
EC Number:
204-824-3
EC Name:
Pyruvic acid
Cas Number:
127-17-3
Molecular formula:
C3H4O3
IUPAC Name:
2-oxopropanoic acid
Test material form:
liquid

Results and discussion

pH valueopen allclose all
Key result
pH value:
1.79
Temp.:
25 °C
Concentration:
100 other: mmol/l
Key result
pH value:
2.38
Temp.:
25 °C
Concentration:
10 other: mmol/l
Key result
pH value:
3.11
Temp.:
25 °C
Concentration:
1 other: mmol/l

Applicant's summary and conclusion

Conclusions:
Handbook data are considered to be from a trusted source acc. to "ECHA, Guidance on information requirements and chemical safety assessment – Chapter R.7a: Endpoint specific guidance", and therefore, the calculated values can be regarded as valid.
Executive summary:

This information is taken from a reliable peer reviewed handbook and so can be considered reliable and suitable for use as the key study for this endpoint.