Registration Dossier
Registration Dossier
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EC number: 204-337-6 | CAS number: 119-61-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Only few data on test method reported. Not sufficient for assessment.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 977
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- (only few data available, 72 h observation, abbrasive sites, no individual scores available for assessment)
- GLP compliance:
- no
Test material
- Reference substance name:
- Benzophenone
- EC Number:
- 204-337-6
- EC Name:
- Benzophenone
- Cas Number:
- 119-61-9
- Molecular formula:
- C13H10O
- IUPAC Name:
- benzophenone
- Details on test material:
- - Name of test material (as cited in study report): Benzophenone
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- other: scratched and unscratched skin sites.
- Vehicle:
- other: olive oil
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL
- Concentration: 20 g in 100 mL - Observation period:
- 72 hours
- Number of animals:
- 6
- Details on study design:
- SCORING SYSTEM: According to Draize Scoring System for erythema and oedema.
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24-72 h
- Score:
- 2
- Irritant / corrosive response data:
- Erythema and oedema: slight in most of the animals; moderate in 1/6 animals; intense in 1/6 animals
- Other effects:
- Histopathology: focal necrosis with or without dyskeratosis.
Applicant's summary and conclusion
- Interpretation of results:
- no data
- Remarks:
- Migrated information (no individual data available for CLP assessment) Criteria used for interpretation of results: EU
- Conclusions:
- The primary irritation index was 2.0. in a 72h exposure period.
- Executive summary:
A primary dermal irritation test was performed with benzophenone. Test item was applied as a 20% dispersion in olive oil to the rabbit skin. The skin was scored for irritation at 24 and 72 hours. Benzophenone had a moderate irritating potential to the scratched and unscratched skin sites with histopathological changes. The primary irritation index was 2.0. in a 72h exposure period.
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