Registration Dossier
Registration Dossier
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EC number: 611-624-3 | CAS number: 581076-67-7
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 27. january 2003 - 26. february 2003
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: well documented and reported study, conducted according to internationally accepted technical guideline. A GLP compliance statement and a Quality Assurance Uni Statement is included in the report.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- N-(3-Guanidino-4-methyl-phenyl)-4-(4-methyl-piperazin-1-ylmethyl)-benzamide, dihydrochloride
- Cas Number:
- 581076-67-7
- Molecular formula:
- Hill formula: C21 H30 Cl2 N6 O CAS formula: C21 H28 N6 O.2Cl H
- IUPAC Name:
- N-(3-Guanidino-4-methyl-phenyl)-4-(4-methyl-piperazin-1-ylmethyl)-benzamide, dihydrochloride
- Details on test material:
- Batch No.: 022401
expiry date: december 2003
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- >= 0.074 - <= 0.075 g/L
- Based on:
- test mat.
Results and discussion
% Degradation
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 9.6
- St. dev.:
- 1
- Sampling time:
- 28 d
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- not inherently biodegradable
- Conclusions:
- According to the results of this study, STI571 F8 cannot be classified as "readily biodegradable".
- Executive summary:
Aim and methods
The biodegradability of "STI571 F8" was analysed by the determination of carbon dioxide evolution at frequent intervals over a 28 d period. The method used was that described in Part C.4-C of the EC Commission Directive 92/69/EEC and in the OECD Guideline 301B.
Results
•The reference substance sodium benzoate was degraded by 63.4% within 10 days.
•Degradation in the toxicity control, which contained sodium benzoate and the test substance, was not indicative of an significant inhibition of the
microbial activity by the test substance.
•The carbon dioxide evolution from "STI571 F8" reached a maximum of 9.6% after 28 days of incubation.
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