2-(2-(2-butoxyethoxy)ethoxy)ethanol

Exposure related observations in humans: other data

Administrative data

Endpoint:

exposure-related observations in humans: other data

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: A published study containing sufficient details to regard it as reliable for use in hazard assessment. Limited experimental detail provided.

Data source

Reference

Reference Type:

publication

Title:

The safety of propylene glycol and other humectants

Author:

Motoyoshi et al

Year:

1984

Bibliographic source:

Cosmetics and Toiletries 99, 83-91

Materials and methods

Type of study / information:

Human skin irritation study

Endpoint addressed:

skin irritation / corrosion

Test guideline

Qualifier:

no guideline required

Principles of method if other than guideline:

48 hr patch test

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

2-(2-ethoxyethoxy)ethanol

EC Number:

203-919-7

EC Name:

2-(2-ethoxyethoxy)ethanol

Cas Number:

111-90-0

IUPAC Name:

2-(2-ethoxyethoxy)ethanol

Details on test material:

EC Number 203-919-7
EC Name 2-(2-ethoxyethoxy)ethanol
CAS Number 111-90-0
Molecular formula C6H14O3
IUPAC Name 2-(2-ethoxyethoxy)ethanol
Type of substance
Composition mono constituent substance
Origin organic
Trade names DEGEE, diethylene glycol methyl ether
diethylene glycol monoethyl ether (Wako Junyaku). Unknown impurities.

Method

Ethical approval:

not specified

Details on study design:

48 hr occlusive patch tests were conducted in 34 health Japanese male adults .
The size of lint used in the patch tests was a 15mm2 and the amount of substance applied was 0.05ml/patch of a 50% (w/w) solution on the upper back. Skin was scored 30 minutes after patch removal.

Exposure assessment:

not specified

Results and discussion

Results:

45% of those tested showed erythema, edema or vesicles. An additional 20 % had definite erythema and approximately 35% had possible erythema.

No other details were reported.

Applicant's summary and conclusion

Conclusions:

The substance 2-(2-(2-butoxyethoxy)ethoxy)ethanol is an analogue of the test substance used in the study.The test substance was a skin irritant under the conditions of this study.

Executive summary:

The substance 2-(2-(2-butoxyethoxy)ethoxy)ethanol is an analogue of the test substance used in the study.In a 48hr occlusive patch irritation study in Japanese subjects, 0.05ml of 50% (w/w) 2 -(2 -ethoxyethoxy)ethanol induce irritation observed as erythema, edema or vesicles in most subjects. Similar results were seen with other tested substances such as propylene and dipropylene glycol.