Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Hazard for aquatic organisms

Freshwater

Hazard assessment conclusion:
PNEC aqua (freshwater)
PNEC value:
50.55 µg/L
Assessment factor:
1 000
Extrapolation method:
assessment factor
PNEC freshwater (intermittent releases):
0.505 mg/L

Marine water

Hazard assessment conclusion:
PNEC aqua (marine water)
PNEC value:
5.055 µg/L
Assessment factor:
10 000
Extrapolation method:
assessment factor

STP

Hazard assessment conclusion:
PNEC STP
PNEC value:
80 mg/L
Assessment factor:
10
Extrapolation method:
assessment factor

Sediment (freshwater)

Hazard assessment conclusion:
PNEC sediment (freshwater)
PNEC value:
0.854 mg/kg sediment dw
Extrapolation method:
equilibrium partitioning method

Sediment (marine water)

Hazard assessment conclusion:
PNEC sediment (marine water)
PNEC value:
0.085 mg/kg sediment dw
Extrapolation method:
equilibrium partitioning method

Hazard for air

Air

Hazard assessment conclusion:
no hazard identified

Hazard for terrestrial organisms

Soil

Hazard assessment conclusion:
PNEC soil
PNEC value:
0.218 mg/kg soil dw
Extrapolation method:
equilibrium partitioning method

Hazard for predators

Secondary poisoning

Hazard assessment conclusion:
no potential for bioaccumulation

Additional information

Aquatic toxicology:

γ-nonalactone is a linear saturated 4-hydroxycarboxylic acid derived-lactone with 9 carbons. γ-decalactone and  γ-undecalactone are structurally similar compounds of aliphatic lactones with 10 and 11 carbons, respectively. These substance are considered adequate for read-across purpose.

A compilation of QSAR results and available experimental values was made for these three lactones. QSAR results were obtained with ECOSAR v1.11 model (Ecological Structure Activity Relationships), which is a computerized predictive system that estimates a chemical's acute and chronic toxicities to aquatic organisms such as fish, aquatic invertebrates, and aquatic plants by using computerized Structure Activity Relationships (SARs).

A correlation between the chemical acute toxicity on each aquatic trophic level (fish, aquatic invertebrates and algae) and the number of carbons was observed, showing that the aquatic toxicity (whatever the organism) increased with the carbon chain length.

In acute conditions, the most sensitive species for γ-nonalactone is fish with an estimated LC50 of 50.55 mg/L.

In accordance with column 2 of REACH annex IX, further testing on the long-term effects on aquatic organisms does not need to be conducted as the chemical safety assessment does not indicate a need for further investigation.

For toxicity to microorganisms, a weight of evidence approach was used with three studies.γ-nonalactone was not considered toxic to microorganisms.

Terrestrial toxicity:

γ-nonalactone is considered as readily biodegradable, it can be assumed that it will be biodegraded within the STP process and as a consequence a transfer to the soil compartment is not expected. For this reason, waiving are proposed for terrestrial toxicity endpoints.

Conclusion on classification

10 mg/L < E(L)C50 < 100 mg/L; readily biodegradable; log Kow = 2.5.

Classification according to the Annex VI of the Directive 67/548/EEC: The test substance is not classified for the environment.

Classification according to the Annex VI of the Regulation (EC) No 1272/2008 (CLP): According to the 2nd ATP, the test substance is not classified for the environment.