Registration Dossier
Registration Dossier
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EC number: 203-219-1 | CAS number: 104-61-0
Endpoint summary
Administrative data
Description of key information
Additional information
γ-nonalactone is a linear saturated 4-hydroxycarboxylic acid derived-lactone with 9 carbons. γ-decalactone is structurally similar compound of aliphatic lactones with 10 carbons. This substance is considered adequate for read-across purpose.
Three studies are available to assess the biodegradation of γ-nonalactone.
The first study, assess as a reliable key study, was performed on γ-decalactone in an aerobic aqueous media, according to OECD Guideline 301F. γ-decalactone attained 82% degradation after 28 days, meeting the 10-day window, and therefore should be considered to be readily biodegradable.
The second study, assess as a not assignable supporting study, was performed on γ-nonalactone in an aerobic aqueous media, according to OECD Guideline 301 C. Due to the lacks of many endpoints required such as pH measurement or details on inoculum preparation, the reliability of this study cannot be evaluated. γ-nonalactone attained 80% degradation after 28 days and therefore should be considered to be readily biodegradable.
The third study, assess as a reliable supporting study, was performed on γ-nonalactone, according to OECD Guideline 301 D. Greater than 60% biodegradation of γ-nonalactone was reached on Day 21 and on Day 28, the biodegradation was 71%. However, γ-nonalactone did probably not meet the 14-day window.
In conclusion, based on a read-across approach and data available on γ-nonalactone, this substance is considered readily biodegradable.
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