Registration Dossier
Registration Dossier
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EC number: 300-344-4 | CAS number: 93925-42-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Remarks:
- other: in vivo: Guinea pig maximisation test
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- july to september 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 406
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: OPPTS 870.2600
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: EU B.6
- Deviations:
- no
- GLP compliance:
- yes
- Remarks:
- Bayrisches Landesamt für Arbeitsschutz, Arbeitsmedizin und Sicherheitstechnik, München, Germany
Test material
- Reference substance name:
- Silicic acid (H4SiO4), tetraethyl ester, reaction products with bis(acetyloxy)dibutylstannane
- EC Number:
- 300-344-4
- EC Name:
- Silicic acid (H4SiO4), tetraethyl ester, reaction products with bis(acetyloxy)dibutylstannane
- Cas Number:
- 93925-42-9
- Molecular formula:
- C12H24O4Sn.C8H20O4Si
- IUPAC Name:
- Acetic acid, 1,1'-(dibutylstannylene) ester, reaction products with silicic acid (H4SiO4) tetra-Et ester
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- Dunkin-Hartley
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: positive and negative control
- Duration of treatment / exposure:
- 48h
- Observation period:
- 72h
- Number of animals:
- 10
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks on result:
- no indication of irritation
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- the test item showed in the sensitization study no irritant properties
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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