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Diss Factsheets

Physical & Chemical properties

Water solubility

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
June 18-June 28, 2010
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study performed in laboratory certified to be compliant with GLP.
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
yes
Remarks:
solubility dependance with pH included
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7840 (Water Solubility)
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
GLP compliance:
no
Remarks:
Performed in laboratory certified to be compliant with GLP.
Type of method:
flask method
Water solubility:
2 g/L
Temp.:
25 °C
pH:
3.6
Remarks on result:
other: pure water; relative standard deviation 1.4%
Water solubility:
2.9 g/L
Temp.:
25 °C
pH:
4.9
Remarks on result:
other: buffered solution pH 4.9; relative standard deviation 1.4%
Water solubility:
9.6 g/L
Temp.:
25 °C
pH:
5.9
Remarks on result:
other: buffered solution pH 5.9; relative standard deviation 1.8%
Details on results:
The pH of each saturated solution was determined following centrifugation.
A comparison of the retention times of the test item in the reference solutions with those in the sample solutions indicated that the identity of the test item had not altered during the experiment.

For all three water qualities investigated: pre-equilibration for different lengths of time (1, 2 or 3 days) at 30.0 °C gave similar results indicating that equilibrium had indeed been reached.

Conclusions:
Interpretation of results (migrated information): soluble (1000-10000 mg/L)
This study is considered to be adequate and reliable.

Description of key information

2.9 g/L, 25°C, pH=4.9, buffered, OECD 105, shake flask, Khot, 2010
9.6 g/L, 25°C, pH=5.9, buffered, OECD 105, shake flask, Khot, 2010
2.0 g/L, 25°C, pH=3.6, OECD 105, shake flask, Khot, 2010

Key value for chemical safety assessment

Water solubility:
2 g/L
at the temperature of:
25 °C

Additional information

For the determination of the water solubility of the substance there is only one study available performed in accordance with the OECD guideline 105. It is considered to be reliable and adequate for classification and labeling, and risk assessment purposes.