Registration Dossier
Registration Dossier
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EC number: 485-320-2 | CAS number: 221667-31-8
PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
The PBT Assessment is based on the criteria set out in the “Guidance on information requirements and chemical safety assessment, Chapter R.11: PBT Assessment” (ECHA, 2017).
Persistence Assessment:
The substance is not readily biodegradable according to OECD criteria (30% after 28d; OECD 301 F).
Degradation half-lives of 144.6 - 335.4 days (recalculated to 12 °C) were determined in two different water/sediment systems under aerobic conditions. The mineralization rates were ≤24.5% AR after 132 days (OECD 308). Under anaerobic conditions degradation half-lives of 442.8 - 452.8 days (recalculated to 12 °C) were determined. No mineralization was observed after 155 days (OECD 308).
The half-lives in aerobic soils (DT50) of the substance were between 2.3 to 10.6 days at 20 °C (4.9 - 22.5 days, recalculated to 12 °C) with a mineralization to 14CO2 of 43 - 61.9% applied radioactivity (AR) after 120 days in four different soils. Under anaerobic conditions, Cyprosulfamide degraded with a half-life of approx. 48.5 – 59.5 days at 20 °C (103 - 126.3 days, recalculated to 12 °C) and 3.1 - 14.3% AR were mineralized to 14CO2 after 180 days.
The substance meets the P and vP criteria.
Bioaccumulation Assessment:
Cyprosulfamide has a low potential for bioaccumulation. The log Pow of Cyprosulfamide was measured to be < 3 (log Pow of 1.77 at 23 °C at pH 4, log Pow of -0.80 at 23 °C at pH 7 and a log Pow of -1.81 at 23 °C at pH 9), which is below the trigger value of 4.5, and no specific uptake mechanism is known or suspected.
Therefore, the substance does not meet the B criterion.
Toxicity Assessment:
All acute and chronic effect concentrations are clearly above the trigger value of <0.01 mg/L. The substance is not classified as carcinogenic, mutagenic or toxic for reproduction nor is there any evidence of chronic toxicity, as identified by the classifications: T, R48, or Xn, R48 according to Directive 67/548/EEC.
The substance does not meet the T criterion.
Summary and overall Conclusions on PBT or vPvB Properties:
The test substance does not fulfil the PBT and vPvB criteria.
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