Registration Dossier
Registration Dossier
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EC number: 211-314-4 | CAS number: 638-03-9
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- not given
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- As m-toluidine hydrochloride dissociates into m-toluidine and hydrochloride the studies concerning the ecotoxicology of m-toludine are considered relevant for the registration according to REACH.
Cross-reference
- Reason / purpose for cross-reference:
- read-across source
Data source
Reference
- Reference Type:
- publication
- Title:
- SIDS initial assessment profile: m-Toluidine (CAS No. 108-44-1)
- Author:
- OECD
- Year:
- 2 001
- Bibliographic source:
- SIAM 11, 23-26 January 2001, pp1-2
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 E (Ready biodegradability: Modified OECD Screening Test)
- Version / remarks:
- modified OECD screening test
- GLP compliance:
- not specified
Test material
- Reference substance name:
- m-toluidine
- EC Number:
- 203-583-1
- EC Name:
- m-toluidine
- Cas Number:
- 108-44-1
- Molecular formula:
- C7H9N
- IUPAC Name:
- m-toluidine
- Test material form:
- not specified
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- other: effluent of predominantly domestic STP
- Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 20 mg/L
- Based on:
- DOC
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- DOC removal
- Details on study design:
- replicates per concentration: 2
Reference substanceopen allclose all
- Reference substance:
- other: hydroquinone
- Reference substance:
- aniline
Results and discussion
% Degradation
- Key result
- Parameter:
- % degradation (DOC removal)
- Value:
- > 64 - < 84
- Sampling time:
- 28 d
- Details on results:
- Degradation of m-toluidine (1st run):
7 d: -24 %*
14 d: 91 %
21 d: 98 %
28 d: 84 %
Degradation of m-toluidine (2nd run):
7 d: - 24 %*
14 d: 83 %
21 d: 91 %
28 d: 64 %
* negative values mean an increase of the DOC in the test system to the control, no explanation is given for these findings
BOD5 / COD results
- Results with reference substance:
- Degradation of aniline fulfilled the pass level as 86 +/- 10 % (mean value) were degraded after 14 d.
Degradation of hydroquinone showed a greater variability, but observed degradation after 14 d reached the pass level.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- The substance m-toluidine is considered readily biodegradable with a degradation of 64% and 84 % after 28 d, respectively. As m-toluidine HCl dissociates in aqueous solution into m-toluidine and hydrochloride the study is considered relevant for the registration of m-toluidine HCl.
- Executive summary:
As m-toluidine HCl dissociates in aqueous solution into m-toluidine and hydrochloride the studies concerning the ecotoxicology of m-toludine are considered relevant for the registration according to REACH.
According to the study by Trenel and Kuehn (1982) m-toluidine is considered readily biodegradable. Thus, as indicated above, m-toluidine HCl will be considered as readily biodegradable as well.
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