Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Study period:
20 September 1996 to 29 October 1996
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1996
Report date:
1996

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
Deviations:
no
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
N-ethyl-N-(3-methylphenyl)propionamide
EC Number:
423-640-6
EC Name:
N-ethyl-N-(3-methylphenyl)propionamide
Cas Number:
179911-08-1
Molecular formula:
C12H17NO
IUPAC Name:
N-ethyl-N-(3-methylphenyl)propanamide
Test material form:
liquid
Radiolabelling:
not specified

Study design

Analytical monitoring:
yes
Details on sampling:
Sample solutions were prepared in stoppered glass flasks at nominal concentrations of 1.50 g/l in the three buffer solutions.
Buffers:
pH4: Citric Acid 0.05 mol dm^-3 / Sodium hydroxide 0.10 mol dm^-3 / Hydrochloric acid 0.05 mol dm^-3
pH7: Disodium hydrogen orthophosphate 0.04 mol dm^-3 / Potassium dihydrogen orthophosphate 0.03 mol dm^-3
pH9: Disodium tetraborate 0.05 mol dm^-3 / Hydrochloric acid 0.02 mol dm^-3

The buffer solutions were filtered through a 0.2 micrometers membrane filter to ensure they were sterile before commencement of the test. Also these solutions were subjected to ultrasonication and degassing with nitrogen to minimise dissoled oxygen content.
Duration of testopen allclose all
Duration:
5 d
pH:
4
Temp.:
50 °C
Initial conc. measured:
>= 1.52 - <= 1.57 g/L
Duration:
5 d
pH:
7
Temp.:
50 °C
Initial conc. measured:
>= 1.47 - <= 1.6 g/L
Duration:
5 d
pH:
9
Temp.:
50 °C
Initial conc. measured:
>= 1.48 - <= 1.61 g/L
Number of replicates:
3
Positive controls:
not specified
Negative controls:
not specified

Results and discussion

Transformation products:
not measured
Dissipation DT50 of parent compoundopen allclose all
Key result
pH:
4
Temp.:
25 °C
DT50:
> 1 yr
Key result
pH:
7
Temp.:
25 °C
DT50:
> 1 yr
Key result
pH:
9
Temp.:
25 °C
DT50:
> 1 yr

Any other information on results incl. tables

Less than 10% hydrolysis after 5 days at 50°C, equivalent to a half-life greater than 1 year at 25°C.

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
The registered substance has been found to undergo less than 10% hydrolysis after 5 days at 50°C in pH 4, 7 and 9 buffer solutions.
The half-life at 25°C has been estimated and is given below:
pH Half-life
4 > 1 year
7 > 1 year
9 > 1 year