fatty acids, C16-C18 (even numbered) and C18 unsaturated, 3-methylbutyl and 2-methylbutyl esters.

Biodegradation in water: screening tests

Link to relevant study record(s)

Reference

Endpoint:

biodegradation in water: ready biodegradability

Type of information:

(Q)SAR

Adequacy of study:

weight of evidence

Study period:

2021

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Justification for type of information:

QSAR prediction from a well accepted model

Qualifier:

no guideline available

Principles of method if other than guideline:

BIOWIN estimates the biodegradation of organic substances. The model is part of the EpiSuite program of the US-EPA. Estimations are made with BIOWIN version 4.10
In the BioWin program, the conclusion on ready biodegradation is estimated from two models.
• Biowin3 estimates complete ultimate biodegradation in a typical aquatic environment
• Biowin5 predicts biodegradability in the Japanese MITI i.e. OECD 301C test
BioWin gives a YES prediction for “Ready Biodegradation” if both of the following conditions are met:

• the ultimate biodegradation (Biowin3) results in weeks, days to weeks or days
• MITI linear model (Biowin5) probability is ≥ 0.5

GLP compliance:

no

Specific details on test material used for the study:

not applicable QSARS

Oxygen conditions:

aerobic

Duration of test (contact time):

28 d

Parameter:

other: QSAR BIOWIN V4.10

Remarks on result:

other: QSAR prediction no quantitative result is avialable

Results with reference substance:

Validity of the model: see QMRF and QPRF

For the dermination of the biodegradation in water a QSAR system is used. The conclusion of BIOWIN is that Fatty acids ,C16 -C18 saturated and unsaturated isopentyl esters is estimated to be readily biodegradable in a standard MITI test (OECD test guideline 301C)

Conclusions:

Fatty acids C16-18, saturated and unsaturated, isopentyl esters, is estimated to be readily biodegradable in a standard MITI test (OECD 301C) by the BIOWIN QSAR model.

Executive summary:

The aerobic biodegradation of Fatty  acids C16-18, saturated and  unsaturated, isopentyl esters, was estimated by BIOWIN version 4.10.This QSAR model is included in the EPI Suite programs developed by Sycracuse Research Corporation for US-EPA. The conclusion of BIOWIN is that Fatty acids C16 -18, saturated and  unsaturated, isopentyl esters  is estimated to be readily biodegradable in a standard MITI test (OECD test guideline 301C). The mineralisation is estimated to take days to weeks and the primary degradation occurs within a timeframe of days. Test results on biodegradation are not available. The calculated result can be used for classification and risk assessment.

Description of key information

Biodegradation for Fatty acids C16-C18, and C18 unsaturated isopentyl esters was

estimated with  QSARS.Fatty acids C16-C18, and C18 unsaturated isopentyl esters was found to be readily biodegradable.

 

Key value for chemical safety assessment

Biodegradation in water:

readily biodegradable