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EC number: 435-860-1 | CAS number: 214417-91-1
Toxicity to other aquatic organisms
Administrative data
Link to relevant study record(s)
Description of key information
The 2 hydrolysis products (HNH and MIBK) do not fulfill the screening criterion for toxicity in the PBT assessment as the acute L(E)C50 values are considered to be >0.1 mg/L, as shown by calculations with the ECOSAR Program.
Additional information
Acute toxicity of the 2 hydrolysis products (HNH and MIBK) to aquatic organisms
For the PBT assessment, the short-term toxicity to fish, the short-term toxicity to aquatic invertebrates and the toxicity to aquatic algae and cyanobacteria of the 2 hydrolysis products (HNH and MIBK) is calculated with the ECOSAR Program (v. 1.00), part of EPI Suite v.4.00. These calculated acute L(E)C50 values are compared to the screening criteria as mentioned in the ECHA Guidance on information requirements and chemical safety assessment Chapter R.11: PBT Assessment (Table R. 11-1), to decide whether the hydrolysis products potentially fulfill the T criterion. All predicted acute L(E)C50's are >0.1 mg/L, for both substances (see the attachments), except a 72h-EC50 of 3.79E-5 mg/L for algae, for HNH. To determine the validity of such a prediction (and the other predictions), the acute L(E)C50's were also predicted for the parent substance BMH and compared to the experimentally determined L(E)C50's. With BMH, a comparable predicted result was obtained (72h-EC50 of 5.33E-5 mg/L). Comparison with the experimentally determined 72h-EC50 for algae, 2.5 mg/L, shows that this prediction can not be considered to be valid. In addition, it is important to note that the predicted acute toxicity of BMH is significant higher than the predicted acute toxicity of the 2 hydrolysis products. For BMH, many predicted acute L(E)C50's are <0.1 mg/L while experimentally derived L(E)C50's are higher (>1 mg/L). Therefore it is considered justified to conclude that also the 2 hydrolysis products (HNH and MIBK) do not fulfill the screening criterion for toxicity in the PBT assessment as the acute L(E)C50 values are considered to be >0.1 mg/L.
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