Registration Dossier
Registration Dossier
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EC number: 435-860-1 | CAS number: 214417-91-1
Endpoint summary
Administrative data
Description of key information
The acute oral study was performed according to OECD Guideline 423 and GLP principles and the acute dermal study was performed according to OECD Guideline 402 and GLP principles.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Oral:
In an acute oral toxicity study, according to OECD 423, male and female rats were exposed via gavage to 2000 mg/kg bw of BMH. Animals were subjected to daily observations and weekly determination of body weight. Macroscopic examination was performed after terminal sacrifice. No mortality occurred. Lethargy was noted in all males on Day 1. No clinical signs were observed among the females. Bodyweight gain was considered normal and no abnormalities at macroscopic examination were found. Therefore, the oral LD50 of BMH in rats was establised to exceed 2000 mg/kg bw.
Dermal:
In an acute dermal study, performed according to OECD 402, male and female rats were exposed by a single occlusive dermal application to 2000 mg/kg bw of BMH for 24 hours. Animals were subjected to daily observations and weekly determination of body weight. Macroscopic examination was performed after terminal sacrifice. No mortality occurred and no clinical signs were observed among the animals. Chromodacryorrhoea of the snout was noted in three males and two females. The animals had recovered from the symptom by days 2 or 3. Bodyweight gain was considered normal and no abnormalities at macroscopic examination were found. Therefore, the dermal LD50 of BMH in rats was establised to exceed 2000 mg/kg bw.
Justification for classification or non-classification
Based on the available data, the substance does not have to be classified for acute toxicity according to the CLP Regulation (EC) No 1272/2008.
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