Registration Dossier
Registration Dossier
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EC number: 422-460-5 | CAS number: 137234-87-8 UK-103,442
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 1996-06-19 to 1996-07-11
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - Shake Flask Method)
- Version / remarks:
- OJ No. L383A, 29.12.92
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- Batch No.: Chichibu Lot 950704
Purity: 95.7% - Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- ca. 0.19
- Temp.:
- 20 °C
- pH:
- >= 6.12 - <= 7.49
- Details on results:
- CONCENTRATION OF TEST SUBSTANCE IN OCTANOL STOCK SOLUTION
The concentration of test substance in the octanol stock solution was determined as 549.24 μg/mL (mean of individual determinations 548.88 and 549.60 μg/mL). The concentration of test substance based on the mass of test substance used was 541.10 μg/mL.
CONCENTRATION AND TOTAL MASS OF TEST SUBSTANCE IN AQUEOUS AND ORGANIC TEST PHASES AFTER PARTITION
The aqueous phase concentrations ranged from 86.340 - 207.03 μg/mL, with pH values of 6.12 - 7.49.
The organic phase concentrations ranged from 134.97 - 327.63 μg/mL.
Quality control data for the aqueous phase analysis gave recoveries of 99.9% and 101.7%.
No peaks were observed in any of the blank solution chromatograms at the characteristic retention time of the test substance, indicating that the analytical method was free from interferences. - Conclusions:
- The partition coefficient (n-octanol/water) of test item has been determined as: log P = 0.19 at 20°C.
- Executive summary:
The octanol/water partition coefficient was determined by the shake-flask method based on EC A8.
The partition coefficient (n-octanol/water) of test itemhasbeen determined as: logP= 0.19 at 20°C.
Reference
Description of key information
The octanol/water partition coefficient was determined by the shake-flask method based on EC A8.
The partition coefficient (n-octanol/water) of test item has been determined as: logP= 0.19 at 20°C.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 0.19
- at the temperature of:
- 20 °C
Additional information
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